TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07475-5 |