NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway

NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway

Abstract Posttraumatic osteoarthritis (PTOA) is closely related to the inflammatory response caused by mechanical injury and leads to joint degeneration. Herein, we aimed to evaluate the role and underlying mechanism of NUMB in PTOA progression. Anterior cruciate ligament transection (ACLT)-induced...

Full description

Bibliographic Details
Main Authors: Zhou Lv, Yuan Ding, Wei Zhang
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Posttraumatic osteoarthritis
NUMB
BTRC
NF-κB
Inflammation
Online Access:https://doi.org/10.1186/s13018-024-04967-7

Internet

https://doi.org/10.1186/s13018-024-04967-7

Similar Items