The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug). A polypharmacology approach is widely applied in the treatment of acquired...

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Bibliographic Details
Main Authors: Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
HIV
AIDS
zidovudine
polypharmacology
multi-target-directed ligand
hybrid
Online Access:https://www.mdpi.com/1420-3049/27/23/8502

Internet

https://www.mdpi.com/1420-3049/27/23/8502

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