Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains.

Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18-85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The impact of repeated vaccination on breadth and durabilit...

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Bibliographic Details
Main Authors: Ivette A Nuñez, Michael A Carlock, James D Allen, Simon O Owino, Krissy K Moehling, Patricia Nowalk, Michael Susick, Kensington Diagle, Kristen Sweeney, Sophia Mundle, Thorsten U Vogel, Simon Delagrave, Moti Ramgopal, Richard K Zimmerman, Harry Kleanthous, Ted M Ross
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5665503?pdf=render