Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization

Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization

Summary: Background: The mechanism of missense alteration at EGFR L792F in patients with non-small cell lung cancer resistant to osimertinib has not been sufficiently clarified. We aimed to explore the critical molecular events and coping strategies in osimertinib resistance due to acquired L792F m...

Full description

Bibliographic Details
Main Authors: Yiting Sun, Yiting Dong, Xijuan Liu, Yundi Zhang, Hua Bai, Jianchun Duan, Zhihua Tian, Xiang Yan, Jie Wang, Zhijie Wang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:EBioMedicine
Subjects:
Non-small cell lung cancer
EGFR
L792F mutation
Osimertinib resistance
M2 macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003826

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422003826

Similar Items