Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

Abstract Background Gene expression is dysregulated in Alzheimer’s disease (AD) patients, both in peripheral blood and post mortem brain. We investigated peripheral whole-blood gene (co)expression to determine molecular changes prior to symptom onset. Methods RNA was extracted and sequenced for 65 c...

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Bibliographic Details
Main Authors: Emma S. Luckett, Magdalena Zielonka, Amine Kordjani, Jolien Schaeverbeke, Katarzyna Adamczuk, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
RNA sequencing
Blood
Transcriptome
Longitudinal study
Amyloid accumulation
Online Access:https://doi.org/10.1186/s13195-023-01242-5

Internet

https://doi.org/10.1186/s13195-023-01242-5

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