In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

Abstract Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in healthy and diseased tissues remains largely unknown. Herein, we describe a method to define spatial glycogen archite...

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Bibliographic Details
Main Authors: Lyndsay E A Young, Lindsey R Conroy, Harrison A Clarke, Tara R Hawkinson, Kayli E Bolton, William C Sanders, Josephine E Chang, Madison B Webb, Warren J Alilain, Craig W Vander Kooi, Richard R Drake, Douglas A Andres, Tom C Badgett, Lars M Wagner, Derek B Allison, Ramon C Sun, Matthew S Gentry
Format: Article
Language:English
Published: Springer Nature 2022-09-01
Series:EMBO Molecular Medicine
Subjects:
Ewing sarcoma
glycogen
glycogen storage disease
MALDI imaging
spatial metabolism
Online Access:https://doi.org/10.15252/emmm.202216029

Internet

https://doi.org/10.15252/emmm.202216029

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