Development and Validation of a Method for the Semi-Quantitative Determination of <i>N</i>-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

Development and Validation of a Method for the Semi-Quantitative Determination of <i>N</i>-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic <i>N</i>-nitrosodimethylamine (NDMA) and <i>N</i>-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate. <i>N</i>-nitrosamine...

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Bibliographic Details
Main Authors: Dariusz Boczar, Elżbieta Wyszomirska, Beata Zabrzewska, Anna Chyła, Katarzyna Michalska
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Applied Sciences
Subjects:
<i>N</i>-nitrosamine
NDMA
NDEA
enalapril
Fmoc-Cl
Online Access:https://www.mdpi.com/2076-3417/11/16/7590

Internet

https://www.mdpi.com/2076-3417/11/16/7590

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