Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk

Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk

Cleft lip with or without cleft palate (CL/P) is a common human birth defect whose etiologies remain largely unknown. Several studies have demonstrated that periconceptional supplementation of folic acid can reduce risk of CL/P in offspring. In this study, we tested the hypothesis that the preventiv...

Full description

Bibliographic Details
Main Authors: Semira Gonseth, Gary M. Shaw, Ritu Roy, Mark R. Segal, Kripa Asrani, Jasper Rine, Joseph Wiemels, Nicholas J. Marini
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:Epigenetics
Subjects:
orofacial cleft
birth defect
epigenetics
dna methylation
metastable epiallele
folic acid
Online Access:http://dx.doi.org/10.1080/15592294.2019.1581591

Internet

http://dx.doi.org/10.1080/15592294.2019.1581591

Similar Items