Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Abstract. Background:. Liver cancer is largely resistant to chemotherapy. This study aimed to identify the effective chemotherapeutics for β-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1 (CTNNB1), the most frequently altered proto-oncogene in hepatic...

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Bibliographic Details
Main Authors: Fangming Liu, Yuting Wu, Baohui Zhang, Shuhui Yang, Kezhuo Shang, Jie Li, Pengju Zhang, Weiwei Deng, Linlin Chen, Liang Zheng, Xiaochen Gai, Hongbing Zhang, Jing Ni
Format: Article
Language:English
Published: Wolters Kluwer 2024-01-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000002816

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http://journals.lww.com/10.1097/CM9.0000000000002816

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