Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

Loss of Neuropilin-2 in Murine Mesenchymal-like Colon Cancer Organoids Causes Mesenchymal-to-Epithelial Transition and an Acquired Dependency on Insulin-Receptor Signaling and Autophagy

Neuropilin-2 (Nrp2), an important regulator of lymphangiogenesis and lymphatic metastasis, has been associated with progression in colorectal cancer (CRC). However, the tumor cell-intrinsic role of Nrp2 in cancer progression is incompletely understood. To address this question, we employed CRISPR-Ca...

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Bibliographic Details
Main Authors: Susanna Poghosyan, Nicola Frenkel, Aristeidis Lentzas, Jamila Laoukili, Inne Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
organoids
colorectal cancer
Neuropilin-2
autophagy
insulin receptor
mesenchymal-to-epithelial transition (MET)
Online Access:https://www.mdpi.com/2072-6694/14/3/671

Internet

https://www.mdpi.com/2072-6694/14/3/671

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