Effects of the Dual FAAH/MAGL Inhibitor AKU-005 on Trigeminal Hyperalgesia in Male Rats

Effects of the Dual FAAH/MAGL Inhibitor AKU-005 on Trigeminal Hyperalgesia in Male Rats

The inhibition of endocannabinoid hydrolysis by enzymatic inhibitors may interfere with mechanisms underlying migraine-related pain. The dual FAAH/MAGL inhibitor AKU-005 shows potent inhibitory activity in vitro. Here, we assessed the effect of AKU-005 in a migraine animal model based on nitroglycer...

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Bibliographic Details
Main Authors: Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Cells
Subjects:
endocannabinoids
FAAH
MAGL
migraine
pain
Online Access:https://www.mdpi.com/2073-4409/13/10/830

Internet

https://www.mdpi.com/2073-4409/13/10/830

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