RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress

RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress

Objective: To investigate the protective effect of bexarotene in radiation-induced skin injury and elucidate underlying mechanism. Methods: Irradiated cellular and animal models were established using an X-ray linear accelerator. Cell viability and apoptosis were evaluated by CCK8 and flow cytometry...

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Bibliographic Details
Main Authors: Sheng Jiang, Weichao Cai, Jianhui Chen, Wenling Tu, Yulan Liu, Lixin Gong, Yahui Feng, Wei Mo, Tao Yan, Shuyu Zhang, Daojiang Yu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Radiation Medicine and Protection
Subjects:
Radiation
Skin injury
Oxidative stress
RXRα
Bexarotene
Online Access:http://www.sciencedirect.com/science/article/pii/S2666555722000247

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http://www.sciencedirect.com/science/article/pii/S2666555722000247

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