Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep

Abstract By identifying endogenous molecules in brain extracellular fluid metabolomics can provide insight into the regulatory mechanisms and functions of sleep. Here we studied how the cortical metabolome changes during sleep, sleep deprivation and spontaneous wakefulness. Mice were implanted with...

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Bibliographic Details
Main Authors: Allen K. Bourdon, Giovanna Maria Spano, William Marshall, Michele Bellesi, Giulio Tononi, Pier Andrea Serra, Helen A. Baghdoyan, Ralph Lydic, Shawn R. Campagna, Chiara Cirelli
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29511-6