Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep
Abstract By identifying endogenous molecules in brain extracellular fluid metabolomics can provide insight into the regulatory mechanisms and functions of sleep. Here we studied how the cortical metabolome changes during sleep, sleep deprivation and spontaneous wakefulness. Mice were implanted with...
Main Authors: | Allen K. Bourdon, Giovanna Maria Spano, William Marshall, Michele Bellesi, Giulio Tononi, Pier Andrea Serra, Helen A. Baghdoyan, Ralph Lydic, Shawn R. Campagna, Chiara Cirelli |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2018-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-29511-6 |
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