Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damages

Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damages

The on-going COVID-19 pandemic has given rise to SARS-CoV-2 clades and variants with differing levels of symptoms and severity. To this end, we aim to systematically elucidate the changes in the pathogenesis as SARS-CoV-2 evolved from ancestral to the recent Omicron VOC, on their mechanisms (e.g. cy...

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Bibliographic Details
Main Authors: Zhen Qin Aw, Chee Keng Mok, Yi Hao Wong, Huixin Chen, Tze Minn Mak, Raymond T. P. Lin, David Chien Lye, Kai Sen Tan, Justin Jang Hann Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
variants of concern
immune response
cytokine storm
K18-hACE2 mice model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.950666/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.950666/full

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