A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

Abstract Background ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO-1301 acts as a cytokine inducer and can initiate tissue repair in a...

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Bibliographic Details
Main Authors: Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa, Shuji Terai
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Inflammation and Regeneration
Subjects:
ONO-1301
Prostacyclin
Prostaglandin I2
Prostaglandin E2
Non-alcoholic steatohepatitis
Online Access:https://doi.org/10.1186/s41232-021-00191-6

Internet

https://doi.org/10.1186/s41232-021-00191-6

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