Vaccine-Induced Th1-Type Response Protects against Invasive Group A <italic toggle="yes">Streptococcus</italic> Infection in the Absence of Opsonizing Antibodies

Vaccine-Induced Th1-Type Response Protects against Invasive Group A <italic toggle="yes">Streptococcus</italic> Infection in the Absence of Opsonizing Antibodies

ABSTRACT Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. H...

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Bibliographic Details
Main Authors: Tania Rivera-Hernandez, Mira Syahira Rhyme, Amanda J. Cork, Scott Jones, Celia Segui-Perez, Livia Brunner, Johanna Richter, Nikolai Petrovsky, Maria Lawrenz, David Goldblatt, Nicolas Collin, Mark J. Walker
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
group A Streptococcus
vaccines
adjuvants
invasive disease
Online Access:https://journals.asm.org/doi/10.1128/mBio.00122-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00122-20

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