Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Abstract Background Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the AVX001 and AVX002 cPLA2α inhibitors were investigated. Methods In vitro...

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Bibliographic Details
Main Authors: A. J. Feuerherm, E. A. Dennis, B. Johansen
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Arthritis Research & Therapy
Subjects:
cPLA2α
Disease-modifying
Anti-rheumatic
Small molecule inhibitors
Online Access:http://link.springer.com/article/10.1186/s13075-018-1794-6

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http://link.springer.com/article/10.1186/s13075-018-1794-6

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