The multiple roles of lipid metabolism in yeast physiology during beer fermentation
Abstract The ability of brewing yeasts (Saccharomyces cerevisiae and Saccharomyces pastorianus) to cope with the toxic effects of ethanol during beer fermentation depends on the modulation of lipid and lipid droplets (LDs) biosynthesis, which affects membrane fluidity. However, it has been demonstra...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2022-09-01
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000300801&tlng=en |
| _version_ | 1828236995147595776 |
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| author | Diego Bonatto |
| author_facet | Diego Bonatto |
| author_sort | Diego Bonatto |
| collection | DOAJ |
| description | Abstract The ability of brewing yeasts (Saccharomyces cerevisiae and Saccharomyces pastorianus) to cope with the toxic effects of ethanol during beer fermentation depends on the modulation of lipid and lipid droplets (LDs) biosynthesis, which affects membrane fluidity. However, it has been demonstrated that lipids and LDs can modulate different biological mechanisms associated to ethanol tolerance, including proteostasis and autophagy, leading to the hypothesis that lipid and LDs biosynthesis are integrative processes necessary for ethanol tolerance in yeast. Supporting this hypothesis, a transcriptome and systems biology analyses indicated the upregulation of autophagy, lipid biosynthesis, and proteostasis (ALP)-associated genes in lager yeast during beer fermentation, whose respective proteins interact in a shortest-pathway ALP network. These results indicated a cross-communication between various pathways linked to inter-organelle autophagy, lipid metabolism, and proteostasis (ALP) during lager beer fermentation, thus highlighting the importance of lipids for beer fermentation. |
| first_indexed | 2024-04-12T20:41:51Z |
| format | Article |
| id | doaj.art-a46867e2689e484f961e7f3e3d742d05 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-12T20:41:51Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-a46867e2689e484f961e7f3e3d742d052022-12-22T03:17:23ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852022-09-0145310.1590/1678-4685-gmb-2021-0325The multiple roles of lipid metabolism in yeast physiology during beer fermentationDiego Bonattohttps://orcid.org/0000-0001-8679-2448Abstract The ability of brewing yeasts (Saccharomyces cerevisiae and Saccharomyces pastorianus) to cope with the toxic effects of ethanol during beer fermentation depends on the modulation of lipid and lipid droplets (LDs) biosynthesis, which affects membrane fluidity. However, it has been demonstrated that lipids and LDs can modulate different biological mechanisms associated to ethanol tolerance, including proteostasis and autophagy, leading to the hypothesis that lipid and LDs biosynthesis are integrative processes necessary for ethanol tolerance in yeast. Supporting this hypothesis, a transcriptome and systems biology analyses indicated the upregulation of autophagy, lipid biosynthesis, and proteostasis (ALP)-associated genes in lager yeast during beer fermentation, whose respective proteins interact in a shortest-pathway ALP network. These results indicated a cross-communication between various pathways linked to inter-organelle autophagy, lipid metabolism, and proteostasis (ALP) during lager beer fermentation, thus highlighting the importance of lipids for beer fermentation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000300801&tlng=enLager yeastslipid metabolismsystems biologytranscriptomicsethanol tolerance |
| spellingShingle | Diego Bonatto The multiple roles of lipid metabolism in yeast physiology during beer fermentation Genetics and Molecular Biology Lager yeasts lipid metabolism systems biology transcriptomics ethanol tolerance |
| title | The multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| title_full | The multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| title_fullStr | The multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| title_full_unstemmed | The multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| title_short | The multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| title_sort | multiple roles of lipid metabolism in yeast physiology during beer fermentation |
| topic | Lager yeasts lipid metabolism systems biology transcriptomics ethanol tolerance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000300801&tlng=en |
| work_keys_str_mv | AT diegobonatto themultiplerolesoflipidmetabolisminyeastphysiologyduringbeerfermentation AT diegobonatto multiplerolesoflipidmetabolisminyeastphysiologyduringbeerfermentation |