Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expansion (>35 copies) of a CAG triplet located in exon 1 of the <i>HTT</i> gene encoding the huntingtin protein (Htt). Mutated Htt (mHtt) easily aggregates, thereby inducing ER stress that...

Full description

Bibliographic Details
Main Authors: Annarita Fiorillo, Veronica Morea, Gianni Colotti, Andrea Ilari
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Personalized Medicine
Subjects:
ubiquitination
huntingtin
E3 ligases
mutated huntingtin clearance
PROTACs
Online Access:https://www.mdpi.com/2075-4426/11/12/1309

Internet

https://www.mdpi.com/2075-4426/11/12/1309

Similar Items