Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

Abstract Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic temporal lobe epilepsy (TLE), and interneuron grafting into the epileptic hippocampus reduces SRS and improves cognitive function. This study investigated whether graft-derived gamma-aminobutyric aci...

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Bibliographic Details
Main Authors: Dinesh Upadhya, Sahithi Attaluri, Yan Liu, Bharathi Hattiangady, Olagide W. Castro, Bing Shuai, Yi Dong, Su-Chun Zhang, Ashok K. Shetty
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00234-7

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https://doi.org/10.1038/s41536-022-00234-7

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