Nkx2‐5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Nkx2‐5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

BackgroundNK2 homeobox 5 (Nkx2‐5) is a cardiac homeobox transcription factor that is expressed in a broad range of cardiac sublineages. Embryos lacking Nkx2‐5 are nonviable attributed to growth retardation and gross abnormalities of the heart. However, the role of Nkx2‐5 in atherosclerosis remains e...

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Bibliographic Details
Main Authors: Meng Du, Xiaojing Wang, Xin Tan, Xiangrao Li, Dandan Huang, Kun Huang, Liu Yang, Fengxiao Zhang, Yan Wang, Dan Huang, Kai Huang
Format: Article
Language:English
Published: Wiley 2016-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
matrix metalloproteinases
NK2 homeobox 5
plaque stability
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004440

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.004440

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