Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells.

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells.

BACKGROUND:Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner. METHODOLOGY/PRINCIPAL FINDINGS:Isolat...

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Bibliographic Details
Main Authors: Mohammed Bensellam, Bertrand Duvillié, Galyna Rybachuk, D Ross Laybutt, Christophe Magnan, Yves Guiot, Jacques Pouysségur, Jean-Christophe Jonas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3250482?pdf=render

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http://europepmc.org/articles/PMC3250482?pdf=render

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