Chk1 haploinsufficiency results in anemia and defective erythropoiesis.

Erythropoiesis is a highly regulated and well-characterized developmental process responsible for providing the oxygen transport system of the body. However, few of the mechanisms involved in this process have been elucidated. Checkpoint Kinase 1 (Chk1) is best known for its role in the cell cycle a...

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Bibliographic Details
Main Authors: Nathan C Boles, Sirisha Peddibhotla, Alice J Chen, Margaret A Goodell, Jeffrey M Rosen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2798715?pdf=render