Overexpression of bovine FcRn in mice enhances T-dependent immune responses by amplifying T helper cell frequency and germinal center enlargement in the spleen

Overexpression of bovine FcRn in mice enhances T-dependent immune responses by amplifying T helper cell frequency and germinal center enlargement in the spleen

The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport and antigen presentation of IgG-opsonized antigens. Previously we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T dependent humoral immune response with...

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Bibliographic Details
Main Authors: Zita eSchneider, Péter Károly Jani, Szikora eBence, Attila eVégh, Dorottya eKövesdi, Attila eIliás, Judit eCervenak, Péter eBalogh, István eKurucz, Imre eKacskovics
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Immunology
Subjects:
Antigen Presentation
Germinal Center
Humoral Immune Response
FcRn overexpression
humoral immune diversity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00357/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00357/full

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