Experimental Comparison of Primary and hiPS-Based In Vitro Blood–Brain Barrier Models for Pharmacological Research

Experimental Comparison of Primary and hiPS-Based In Vitro Blood–Brain Barrier Models for Pharmacological Research

In vitro model systems of the blood–brain barrier (BBB) play an essential role in pharmacological research, specifically during the development and preclinical evaluation of new drug candidates. Within the past decade, the trend in research and further development has moved away from models based on...

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Bibliographic Details
Main Authors: Karin Danz, Tara Höcherl, Sascha Lars Wien, Lena Wien, Hagen von Briesen, Sylvia Wagner
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
blood–brain barrier (BBB)
in vitro model system
human induced pluripotent stem cells (hiPSs)
directed differentiation
brain capillary endothelial cells (BCECs)
Online Access:https://www.mdpi.com/1999-4923/14/4/737

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https://www.mdpi.com/1999-4923/14/4/737

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