Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Systemic AA amyloidosis is caused by misfolding of the acute phase protein serum amyloid A1. Here the authors present the cryo-EM structures of murine and human AA amyloid fibrils that were isolated from tissue samples and describe how the fibrils differ in their fundamental structural properties.

Bibliographic Details
Main Authors: Falk Liberta, Sarah Loerch, Matthies Rennegarbe, Angelika Schierhorn, Per Westermark, Gunilla T. Westermark, Bouke P. C. Hazenberg, Nikolaus Grigorieff, Marcus Fändrich, Matthias Schmidt
Format: Article
Language:English
Published: Nature Portfolio 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09033-z

Internet

https://doi.org/10.1038/s41467-019-09033-z

Similar Items