Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1

Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1

Temporomandibular joint osteoarthritis (TMJOA) condylar cartilage degeneration and abnormal subchondral bone pathological remodeling induce pain and joint dysfunction, and cartilage degeneration is considered irreversible. Very few therapeutic approaches are administrated in practice. Nucleotides ha...

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Bibliographic Details
Main Authors: Hexu Qi, Zhenxing Zhao, Lin Xu, Yue Zhang, Yifei Li, Li Xiao, Yu Li, Zhihe Zhao, Jie Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
TMJOA
miR-181a-5p
antisense oligonucleotide
SIRT1
gene therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.898334/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.898334/full

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