Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics

Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics

Microtubule dynamics are crucial for multiple cell functions, and cancer cells are particularly sensitive to microtubule-modulating agents. Here, we describe the design and synthesis of a series of (Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-phenylacetamide derivatives and evaluation of t...

Full description

Bibliographic Details
Main Authors: Xiang Zhou, Jiamin Liu, Jiao Meng, Yihong Fu, Zhibin Wu, Guiping Ouyang, Zhenchao Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
microtubule
antiproliferative activity
tubulin stabiliser
taxol binding domains
Online Access:http://dx.doi.org/10.1080/14756366.2021.1975695

Internet

http://dx.doi.org/10.1080/14756366.2021.1975695

Similar Items