Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders

Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders

The linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin ligase composed of the Heme-oxidized IRP2 ubiquitin ligase-1L (HOIL-1L), HOIL-1L-interacting protein (HOIP), and Shank-associated RH domain interactor (SHARPIN) subunits. LUBAC specifically generates the N-terminal Met1-linked linear...

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Bibliographic Details
Main Authors: Daisuke Oikawa, Yusuke Sato, Hidefumi Ito, Fuminori Tokunaga
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
inflammation
inhibitor
innate immune
interferon
LUBAC
NF-κB
Online Access:https://www.mdpi.com/1422-0067/21/9/3381

Internet

https://www.mdpi.com/1422-0067/21/9/3381

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