Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice

Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice

Pancreatic fibrosis is an important pathophysiological feature of chronic pancreatitis (CP). Our recent study has shown that milk fat globule-EGF factor 8 (MFG-E8) is beneficial in acute pancreatitis. However, its role in CP remained unknown. To study this, CP was induced in male adult Mfge8-knockou...

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Bibliographic Details
Main Authors: Yifan Ren, Qing Cui, Jia Zhang, Wuming Liu, Meng Xu, Yi Lv, Zheng Wu, Yuanyuan Zhang, Rongqian Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
chronic pancreatitis
MFG-E8
fibrosis
pancreatic stellate cell
chaperone-mediated autophagy
LAMP2A
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.707259/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.707259/full

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