Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

The rapid protease degradation of peptides is currently limiting their therapeutic utility. Here, the authors report functionalised thiocarbazate scaffolds as precursors of aza-amino acids that can be integrated in peptide sequences, extending their bioavailability, and demonstrate this on FSSE/P577...

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Bibliographic Details
Main Authors: Ahmad Altiti, Mingzhu He, Sonya VanPatten, Kai Fan Cheng, Umair Ahmed, Pui Yan Chiu, Ibrahim T. Mughrabi, Bayan Al Jabari, Ronald M. Burch, Kirk R. Manogue, Kevin J. Tracey, Betty Diamond, Christine N. Metz, Huan Yang, LaQueta K. Hudson, Stavros Zanos, Myoungsun Son, Barbara Sherry, Thomas R. Coleman, Yousef Al-Abed
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34712-9

Internet

https://doi.org/10.1038/s41467-022-34712-9

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