Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation

Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation

CYP2J2 is the main epoxygenase in the heart that is responsible for oxidizing arachidonic acid to <i>cis</i>-epoxyeicosatrienoic acids (EETs). Once formed, EETs can then be hydrolyzed by soluble epoxide hydrolase (sEH, encoded by <i>EPHX2</i>) or re-esterified back to the mem...

Full description

Bibliographic Details
Main Authors: Theresa Aliwarga, Jean C. Dinh, Scott Heyward, Bhagwat Prasad, Sina A. Gharib, Rozenn N. Lemaitre, Nona Sotoodehnia, Rheem A. Totah
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
EETs
<i>cis</i>-EET
<i>trans</i>-EET
CYP2J2
Cytochrome P450
POR
Online Access:https://www.mdpi.com/1422-0067/23/20/12433

Internet

https://www.mdpi.com/1422-0067/23/20/12433

Similar Items