Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway

Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway

Abstract This study investigated the protective effect of desoxyrhapontigenin (DOP) against isoflurane (ISF)-induced neuronal injury in rats. Neuronal injury was induced in pups by exposing them to 0.75% ISF on postnatal day 7 with 30% oxygen for 6 h. The pups were treated with DOP 10 mg/kg, i.p., f...

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Bibliographic Details
Main Authors: Feng Liang, Xin Fu, Yunpengfei Li, Fanglei Han
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:AMB Express
Subjects:
Desoxyrhapontigenin
Neuronal injury
Isoflurane
Apoptosis
TLR-4
Sirtuin
Online Access:http://link.springer.com/article/10.1186/s13568-020-01105-4

Internet

http://link.springer.com/article/10.1186/s13568-020-01105-4

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