Simvastatin Inhibits <i>Brucella abortus</i> Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model

Simvastatin Inhibits <i>Brucella abortus</i> Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model

Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase and has been found to have protective effects against several bacterial infections. In this study, we investigate the effects of simvastatin treatment on RAW 264.7 macrophage cells and ICR mice against <i>Brucella</i>...

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Bibliographic Details
Main Authors: Trang Thi Nguyen, Heejin Kim, Tran Xuan Ngoc Huy, Wongi Min, Hujang Lee, Alisha Wehdnesday Bernardo Reyes, Johnhwa Lee, Suk Kim
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Brucella abortus</i>
simvastatin
mevalonate pathway
phagocytosis
immune response
RAW 264.7 cell
Online Access:https://www.mdpi.com/1422-0067/23/15/8337

Internet

https://www.mdpi.com/1422-0067/23/15/8337

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