In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis

In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis

Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause severe adverse effects, and thus, the search for new drugs more effective and less toxic is relevant. We have previously investigated the immu...

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Main Authors: Dahara Keyse Carvalho Silva, Jessicada Silva Teixeira, Diogo Rodrigo Magalhães Moreira, Tiago Fernandes da Silva, Eliezer Jesus de Lacerda Barreiro, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, André Lacerda Braga Teles, Elisalva Teixeira Guimarães, Milena Botelho Pereira Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
Leishmania amazonensis
LASSBio-1386
treatment
N-acyl hydrazones
phosphodiesterase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.590544/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.590544/full

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