RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

Summary: Tumors with mutations in chromatin regulators present attractive targets for DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) therapy, which further disrupts cancer cells’ epigenomic fidelity and reactivates transposable element (TE) expression to drive viral mimicry responses. SETD2...

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Bibliographic Details
Main Authors: Hong-Tao Li, H. Josh Jang, Krizia Rohena-Rivera, Minmin Liu, Hemant Gujar, Justin Kulchycki, Shuqing Zhao, Sandrin Billet, Xinyi Zhou, Daniel J. Weisenberger, Inderbir Gill, Peter A. Jones, Neil A. Bhowmick, Gangning Liang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300027X

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http://www.sciencedirect.com/science/article/pii/S221112472300027X

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