RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer
Summary: Tumors with mutations in chromatin regulators present attractive targets for DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) therapy, which further disrupts cancer cells’ epigenomic fidelity and reactivates transposable element (TE) expression to drive viral mimicry responses. SETD2...
| Hauptverfasser: | , , , , , , , , , , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Elsevier
2023-01-01
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| Schriftenreihe: | Cell Reports |
| Schlagworte: | |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S221112472300027X |