The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with neurotransmitter receptors were investigated in radioligand b...

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Bibliographic Details
Main Authors: Elena K. Schneider, Rachel M. McQuade, Vincenzo C. Carbone, Felisa Reyes-Ortega, John W. Wilson, Brenda Button, Ayame Saito, Daniel P. Poole, Daniel Hoyer, Jian Li, Tony Velkov
Format: Article
Language:English
Published: European Respiratory Society 2018-03-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/4/1/00127-2017.full

Internet

http://openres.ersjournals.com/content/4/1/00127-2017.full

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