Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma

Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma

Summary: Background: Medulloblastoma is the most frequent brain malignancy of childhood. The current multimodal treatment comes at the expense of serious and often long-lasting side effects. Drug repurposing is a strategy to fast-track anti-cancer therapy with low toxicity. Here, we showed the abil...

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Bibliographic Details
Main Authors: Maïlys Rossi, Julie Talbot, Patricia Piris, Marion Le Grand, Marie-Pierre Montero, Mélanie Matteudi, Emilie Agavnian-Couquiaud, Romain Appay, Céline Keime, Daniel Williamson, Duje Buric, Véronique Bourgarel, Laetitia Padovani, Steven C. Clifford, Olivier Ayrault, Eddy Pasquier, Nicolas André, Manon Carré
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Beta-blockers
Bioenergetics
Medulloblastoma
Radiotherapy
Therapeutic combinations
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003309

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http://www.sciencedirect.com/science/article/pii/S2352396422003309

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