Improved Syntheses of the mGlu5 Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

The Sonogashira cross-coupling, a key step in the syntheses of the mGlu5 antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synthes...

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Bibliographic Details
Main Authors: Boshuai Mu, Linjing Mu, Roger Schibli, Simon M. Ametamey, Selena Milicevic Sephton
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Pharmaceuticals
Subjects:
Online Access:http://www.mdpi.com/1424-8247/11/1/24