Improved Syntheses of the mGlu5 Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

Improved Syntheses of the mGlu5 Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

The Sonogashira cross-coupling, a key step in the syntheses of the mGlu5 antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synthes...

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Bibliographic Details
Main Authors:	Boshuai Mu, Linjing Mu, Roger Schibli, Simon M. Ametamey, Selena Milicevic Sephton
Format:	Article
Language:	English
Published:	MDPI AG 2018-02-01
Series:	Pharmaceuticals
Subjects:	Sonogashira cross-coupling MMPEP MTEP mGlu5 antagonist
Online Access:	http://www.mdpi.com/1424-8247/11/1/24

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