Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design.
The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insuf...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Sprog: | English |
| Udgivet: |
Public Library of Science (PLoS)
2015-01-01
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| Serier: | PLoS ONE |
| Online adgang: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138069&type=printable |