Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma

Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma

BackgroundSialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) was reported to be a novel immune checkpoint molecule comparable to programmed cell death 1 ligand 1 (PD-L1). However, its expression profile and immunosuppressive mechanisms in the glioma tumor microenvironment have not yet bee...

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Bibliographic Details
Main Authors: Quan Chen, Bingkun Chen, Chunhua Wang, Li Hu, Qiongwen Wu, Yanyang Zhu, Qiuyu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
Siglec-15
glioma
macrophage
combination therapy
tumor microenvironment
PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1159085/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1159085/full

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