Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity

Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity

Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to enhance inhibitory transmission. Because early inhibitory neurotransmission sculpts functional neuronal circuits, its developmental alteration may have grave consequences. Here, we investigated the acute effects of I...

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Bibliographic Details
Main Authors: Noah Döhne, Alice Falck, Gabriel M. S. Janach, Egor Byvaltcev, Ulf Strauss
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
IFN-γ
type-II interferon
cerebral cortex
neuroimmunology
phasic inhibition
MEA
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.913299/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.913299/full

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