PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer

PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) lacks biomarkers for targeted therapy. Auger emitters display the best therapeutic effect, if delivered directly into the nucleus proximal to DNA. The nuclear protein Poly (ADP-ribose)-Polymerase 1 (PARP1) is a suitable target against which fe...

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Bibliographic Details
Main Authors: Ramya Ambur Sankaranarayana, Alexandru Florea, Susanne Allekotte, Andreas T. J. Vogg, Jochen Maurer, Laura Schäfer, Carsten Bolm, Steven Terhorst, Arno Classen, Matthias Bauwens, Agnieszka Morgenroth, Felix M. Mottaghy
Format: Article
Language:English
Published: SpringerOpen 2022-09-01
Series:EJNMMI Research
Subjects:
TNBC
PARP inhibitors
Targeted radionuclide therapy
Auger emitter
125I
123I
Online Access:https://doi.org/10.1186/s13550-022-00932-9

Internet

https://doi.org/10.1186/s13550-022-00932-9

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