Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral...

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Bibliographic Details
Main Authors: Atsuko Ohkubo, Tomomi Chida, Hidetomo Kikuchi, Tadashi Tsuda, Katsuyoshi Sunaga
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Food–drug interactions
Tomato juice
Grapefruit juice
Nifedipine
Midazolam
Pharmacokinetic interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616301878

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http://www.sciencedirect.com/science/article/pii/S1818087616301878

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