Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of the in vitro culture of ovarian cortical tissue strips

Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of the in vitro culture of ovarian cortical tissue strips

Introduction: We report the development and preliminary evaluation of a novel dynamic bioreactor to culture ovarian cortical tissue strips that leverages tissue response to enhanced oxygen transport and adequate mechanical stimulation. In vitro multistep ovarian tissue static culture followed by mat...

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Bibliographic Details
Main Authors: Gionata Fragomeni, Luigi De Napoli, Vincenza De Gregorio, Vincenzo Genovese, Vincenza Barbato, Giuseppe Serratore, Giuseppe Morrone, Angela Travaglione, Andrea Candela, Roberto Gualtieri, Riccardo Talevi, Gerardo Catapano
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioreactor
dynamic culture
fluid dynamic stimulation
mechanical stimulation
ovarian tissue
oxygen transport
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1310696/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2024.1310696/full

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