Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm

Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm

Mammalian oocyte activation is initiated by intracellular calcium (Ca<sup>2+</sup>) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation capacity. The application of antigen unmasking/retrieval...

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Bibliographic Details
Main Authors: Junaid Kashir, Bhavesh V. Mistry, Lujain BuSaleh, Michail Nomikos, Sarah Almuqayyil, Raed Abu-Dawud, Nadya AlYacoub, Hamdan Hamdan, Saad AlHassan, F. Anthony Lai, Abdullah M. Assiri, Serdar Coskun
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
phospholipase C zeta (PLCzeta)
oocyte activation
male infertility
sperm
fertilisation
antigen retrieval/unmasking
Online Access:https://www.mdpi.com/1424-8247/16/2/198

Internet

https://www.mdpi.com/1424-8247/16/2/198

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